Precambrian-Based β-Lactamases: Heat-Stable, “Promiscuous”
نویسندگان
چکیده
منابع مشابه
Hyperstability and substrate promiscuity in laboratory resurrections of Precambrian β-lactamases.
We report a sequence reconstruction analysis targeting several Precambrian nodes in the evolution of class-A β-lactamases and the preparation and experimental characterization of their encoded proteins. Despite extensive sequence differences with the modern enzymes (~100 amino acid differences), the proteins resurrected in the laboratory properly fold into the canonical lactamase structure. The...
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ژورنال
عنوان ژورنال: Microbe Magazine
سال: 2013
ISSN: 1558-7452,1558-7460
DOI: 10.1128/microbe.8.237.1